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Difference between revisions of "Macropolycytes"

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Revision as of 13:46, 9 November 2019


Appearance:


Neutrophils that are significantly larger than normal, their nuclei may appear hypersegmented at first sight but in fact consist of two distinct nuclei that have normal lobation. Sometimes the nuclei overlap, in other cases they may almost appear as mirror images.





Cause:


Macropolycytes are tetraploid neutrophils with two separate nuclei within a single cell (i.e. they are produced by nuclear division without cytoplasmic division), often occuring during accelerated myelopoiesis. They have been reported in adults with pernicious anaemia, myeloid leukaemias, sepsis, or following cytotoxic chemotherapy.


Consider:

It is easy to initially confuse these appearances with neutrophil hypersegmentation, it is important to recognise the significantly increased size of macropolycytes, and the two separate nuclei.