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Difference between revisions of "Jordans anomaly"

From www.haematologyetc.co.uk

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Images of Jordans anomaly
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'''''Images of Jordans anomaly:''' Typical vacuolation affecting neutrophil (image 1), eosinophil (image 2) and monocyte (image 3)''
  
 
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Revision as of 20:27, 8 November 2019


Appearance:

There is widespread accumulation of lipid in the cytoplasm of many cells and in occasional nuclei. In blood cells this appears as widespread vacuolation affecting granulocytes and monocytes



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Images of Jordans anomaly: Typical vacuolation affecting neutrophil (image 1), eosinophil (image 2) and monocyte (image 3)


Cause:

in neutral lipid storage diseases there is defective triglyceride breakdown causing an accumulation of lipid in cells


Described by:


Dr. G. H. Jordans (1953) in a family with muscular dystrophy


Significance:


Arises in the context of significant congenital disorder, distinguish from other causes such as activation or artefact.