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Difference between revisions of "Gallery: APL"

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File:M3_f.jpg|APL cell containing Auer rods|link={{filepath:M3_f.jpg}}
 
File:M3_f.jpg|APL cell containing Auer rods|link={{filepath:M3_f.jpg}}
 
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'''Recap''' Microgranular (hypogranular) APL: The blasts are often more numerous and have a very distinct appearance - most commonly a bi-lobed nucleus where the very soft chromatin makes the appearance almost transparent. There is little or no granulation in most cells, although occasional hypergranular forms may be detected.
 
 
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File:M3v_a.jpg|Hypogranular APL with typical folded nuclei|link={{filepath:M3v_a.jpg}}
 
File:M3v_b.jpg|Hypogranular APL but containing a long Auer rod|link={{filepath:M3v_b.jpg}}
 
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Revision as of 00:31, 27 March 2020

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Recap Hypergranular APL: The number of abnormal cells in blood is usually low in the hypergranular form. The blast cells tend to be large and vary markedly in size. The cytoplasm is densely packed by large granules that may obscure the nuclear appearance. In some cells rod-like structures may occur in bundles (basket cells). APL cells differ from normal promyelocytes since in normal cells the Golgi zone is generally more obvious, and the granules are more uniform and dispersed.




Other aspects:

Look also for features of an associated coagulopathy, which is caused by release of the abnormal granule contents with a resulting clotting factor activation, and occurs in both forms of APL. In particular look for fragmented or damaged red cells and a disproportionate thrombocytopenia.



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