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Difference between revisions of "Gallery: APL"

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<span style="color:navy">''Remember you can click on the image for a single page view''</span>
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<gallery widths="180px" heights="180px" >
 
<gallery widths="180px" heights="180px" >
File:M3_a.jpg|Granular blast|link={{filepath:M3_a.jpg}}
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File:M3_a.jpg|Large hypergranular APL with bundled rods|link={{filepath:M3_a.jpg}}
File:M3_b.jpg|Blast with scanty granules|link={{filepath:M3_b.jpg}}
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File:M3_b.jpg|Bilobed APL with dense granules|link={{filepath:M3_b.jpg}}
File:M3_c.jpg|Blast with a single composite granule|link={{filepath:.M3_c.jpg}}
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File:M3_c.jpg|Densely granulated APL cell|link={{filepath:M3_c.jpg}}
File:M3_f.jpg|Blast with a single composite granule|link={{filepath:.M3_f.jpg}}
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File:M3_f.jpg|APL cell containing Auer rods|link={{filepath:M3_f.jpg}}
 
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File:M3v_a.jpg|Granular blast|link={{filepath:M3v_a.jpg}}
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File:M3v_a.jpg|Hypogranular APL with typical folded nuclei|link={{filepath:M3v_a.jpg}}
File:M3v_b.jpg|Blast with scanty granules|link={{filepath:M3v_b.jpg}}
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File:M3v_b.jpg|Hypogranular APL but containing a long Auer rod|link={{filepath:M3v_b.jpg}}
File:M3v_c.jpg|Blast with a single composite granule|link=M3v_c={{filepath:.3jpg}}
 
 
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''Other aspects:'' Look also for features of an associated coagulopathy which is caused by the contents of the abnormal granules and occurs in both forms of APL. In particular look for fragmented red cells and a disproportionate thrombocytopenia.
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'''Other aspects:'''
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Look also for features of an associated coagulopathy which is caused by the contents of the abnormal granules and occurs in both forms of APL. In particular look for fragmented red cells and a disproportionate thrombocytopenia.
  
  
 
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Revision as of 11:56, 26 March 2020

Remember you can click on the image for a single page view



RECAP Hypergranular APL: The number of abnormal cells in blood is usually low in the hypergranular form. The blast cells tend to be large and vary markedly in size. The cytoplasm is densely packed by large granules that may obscure the nuclear appearance. In some cells rod-like structures may occur in bundles (basket cells). APL cells differ from normal promyelocytes since in normal cells the Golgi zone is generally more obvious, and the granules are more uniform and dispersed.



RECAP Microgranular (hypogranular) APL: The blasts are often more numerous and have a very distinct appearance - most commonly a bi-lobed nucleus where the very soft chromatin makes the appearance almost transparent. There is little or no granulation in most cells, although occasional hypergranular forms may be detected.


Other aspects:

Look also for features of an associated coagulopathy which is caused by the contents of the abnormal granules and occurs in both forms of APL. In particular look for fragmented red cells and a disproportionate thrombocytopenia.