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Difference between revisions of "Gallery: AML with maturation"

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''Major features:'' Blast are medium sized with basophilic cytoplasm. The nucleus is primitive and is most often offset because of the golgi body (visible as a plae area adjacent to the nucleus). Granulation may be indistinct or obvious and involve >10% of cells, granules may coalesce and form one or more masses and Auer rods are frequently present.  
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'''RECAP:''' Blast have medium size and basophilic cytoplasm. The nucleus is primitive, and is most often offset because of the golgi body (visible as a pale area adjacent to the nucleus in all the panels below). Granulation may be obvious (A) or scanty (B) and involves >10% of cells. The granules may coalesce and form one or more masses (C). Auer rods are frequently present.  
 
 
''Other aspects:'' In some cases there may be maturation to form mature neutrophils (although most often these have atypical appearance) and may form eosinophils or basophils. There is a  frequent occurrence of the t[8.21] chromosomal translocation in this group and these cases may have relatively specific additional features (see separate description in the associated images).
 
 
 
  
 
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File:M2_c.jpg|Blast with a single composite granule|link=M2_c={{filepath:.3jpg}}
 
File:M2_c.jpg|Blast with a single composite granule|link=M2_c={{filepath:.3jpg}}
 
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''Other aspects:'' In some cases there may be maturation to form mature neutrophils (although most often these will have atypical appearance) and may form eosinophils or basophils. There is a  frequent occurrence of the t[8.21] chromosomal translocation in this group.
  
 
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Revision as of 10:47, 26 March 2020


RECAP: Blast have medium size and basophilic cytoplasm. The nucleus is primitive, and is most often offset because of the golgi body (visible as a pale area adjacent to the nucleus in all the panels below). Granulation may be obvious (A) or scanty (B) and involves >10% of cells. The granules may coalesce and form one or more masses (C). Auer rods are frequently present.



Other aspects: In some cases there may be maturation to form mature neutrophils (although most often these will have atypical appearance) and may form eosinophils or basophils. There is a frequent occurrence of the t[8.21] chromosomal translocation in this group.