CD5: Difference between revisions
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<span style="color:navy">'''Normal expression and function'''</span> | <span style="color:navy">'''Normal expression and function'''</span> | ||
CD5 belongs to the scavenger-receptor cysteine rich superfamily that binds to the B-cell ligand CD72. CD5 has a negative effect on T and B cell receptor signalling, so that in B cells it raises the threshold for response to antigen (possibly limiting responses to self-antigens) | |||
Revision as of 17:11, 30 April 2023
- Summary
- For mature B cell neoplasms: CD5 is used to indicate likely CLL or MCL. However, expression is present on a subset of normal B cells, and also less frequently on other lymphoma types. Full interpretation therefore requires consideration of clonality and other markers.
- In acute lymphoblastic leukaemia: CD5 is useful to indicate T lineage, with (relatively) low levels of aberrant expression.
Normal expression and function
CD5 belongs to the scavenger-receptor cysteine rich superfamily that binds to the B-cell ligand CD72. CD5 has a negative effect on T and B cell receptor signalling, so that in B cells it raises the threshold for response to antigen (possibly limiting responses to self-antigens)
Diagnostic role
- xxxxx
Other relevant information:
xxxxx
SUMMARY TABLES