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Difference between revisions of "CD43"

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:CD43 (sialophorin) has a wide range of expression that includes T lymphocytes, monocytes, and granulocytes. CD43 is expressed by many normal B lymphocytes, but expression is absent from resting cells.  
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:CD43 (sialophorin) has a wide range of expression that includes T lymphocytes, monocytes, and granulocytes. CD43 is expressed by many normal activated B lymphocytes, but expression is absent from resting B cells.  
  
  
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Diagnostically, the useful property of CD43 relates to its variable expression on B lymphocyte neoplasms.
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Diagnostically, the vlaue of CD43 relates to its variable expression between B lymphocyte neoplasms.
  
  
 
<span style="color:navy">'''Usage'''</span>  
 
<span style="color:navy">'''Usage'''</span>  
  
*CD43 expression in CLL is >95% including atypical CLL cases, while in MCL cases its expressed by around 40% of cases.  
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*CD43 expression in CLL is >95% including atypical CLL cases, while in MCL it is expressed by around 40% of cases.  
 
*This gives it some value in diagnosing cases of atypical CLL,  
 
*This gives it some value in diagnosing cases of atypical CLL,  
 
*However, CD43 is probably less useful than CD200 for distinguishing CLL and MCL.  
 
*However, CD43 is probably less useful than CD200 for distinguishing CLL and MCL.  

Latest revision as of 15:24, 10 October 2019


CD43 (sialophorin) has a wide range of expression that includes T lymphocytes, monocytes, and granulocytes. CD43 is expressed by many normal activated B lymphocytes, but expression is absent from resting B cells.



Diagnostically, the vlaue of CD43 relates to its variable expression between B lymphocyte neoplasms.


Usage

  • CD43 expression in CLL is >95% including atypical CLL cases, while in MCL it is expressed by around 40% of cases.
  • This gives it some value in diagnosing cases of atypical CLL,
  • However, CD43 is probably less useful than CD200 for distinguishing CLL and MCL.
  • CD43 is rarely expressed in follicular lymphoma.


Note also In hematopathology, CD43 is often considered as a T-cell associated marker, because it is expressed by over 95% of thymocytes and peripheral blood T-cells. Loss of CD43 is seen in Wiskott–Aldrich syndrome.