CD43: Difference between revisions
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:<span style="color:navy">'''Background'''</span> | :<span style="color:navy">'''Background'''</span> | ||
:CD43 sialophorin that is widely expressed accross T lymphocytes, monocytes and granulocytes. In the B-cell lineage however CD43 has vaiable expression being mainly present on normal activated | :CD43 sialophorin that is widely expressed accross T lymphocytes, monocytes and granulocytes. In the B-cell lineage however CD43 has vaiable expression being mainly present on normal activated B lymphocytes, but absent from resting B cells - this variable expression give the marker value in the diagnosis of B-lymphocyte neoplasms. | ||
:<span style="color:navy">'''Diagnostic Use'''</span> | :<span style="color:navy">'''Diagnostic Use'''</span> | ||
* | *CD43 is expressed by 95% of CLL including atypical cases, while in MCL it is expressed by around 40% of cases, this gives it some value in diagnosing cases of atypical CLL although it is probably less useful than CD200 for distinguishing CLL and MCL. | ||
*CD43 is rarely expressed in follicular lymphoma. | |||
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Latest revision as of 20:36, 10 May 2023
- Summary
- Diagnostically the vlaue of CD43 relates to its variable expression between different B-lymphocyte neoplasms that gives it some diagnostic value in the recognition of CLL.
- Background
- CD43 sialophorin that is widely expressed accross T lymphocytes, monocytes and granulocytes. In the B-cell lineage however CD43 has vaiable expression being mainly present on normal activated B lymphocytes, but absent from resting B cells - this variable expression give the marker value in the diagnosis of B-lymphocyte neoplasms.
- Diagnostic Use
- CD43 is expressed by 95% of CLL including atypical cases, while in MCL it is expressed by around 40% of cases, this gives it some value in diagnosing cases of atypical CLL although it is probably less useful than CD200 for distinguishing CLL and MCL.
- CD43 is rarely expressed in follicular lymphoma.