CD1a: Difference between revisions
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(Created page with "A T cell marker that has value in specific circumstances Background CD1a is structurally related to major histocompatibility complex proteins and is thought to mediate the presentation of lipid and glycolipid antigens. CD1a expression is absent on very early thymocytes, but is acquired together with CD4 and CD8 as T cells develop in the thymus, then is lost in mature T cells. Diagnostic Use :A marker of early T-lineage :CD1A us useful in the identification of some cas...") |
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Background | <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> | ||
:<span style="color:navy">'''Summary'''</span> | |||
:A T cell marker that has value for demonstrating T-lineage in specific diagnostic circumstances | |||
</div> | |||
:<span style="color:navy">'''Background'''</span> | |||
CD1a is structurally related to major histocompatibility complex proteins and is thought to mediate the presentation of lipid and glycolipid antigens. CD1a expression is absent on very early thymocytes, but is acquired together with CD4 and CD8 as T cells develop in the thymus, then is lost in mature T cells. | CD1a is structurally related to major histocompatibility complex proteins and is thought to mediate the presentation of lipid and glycolipid antigens. CD1a expression is absent on very early thymocytes, but is acquired together with CD4 and CD8 as T cells develop in the thymus, then is lost in mature T cells. | ||
Diagnostic Use | |||
:<span style="color:navy">'''Diagnostic Use'''</span> | |||
*A marker of early T-lineage | |||
*CD1A us useful in the identification of some cases of T-all and for showing T lineage in MPAL | |||
*Absence of CD1A staining may be helpful in recognition of ETP-ALL | |||
*Aberrant expression of CD1A is recognised to occur at both B cells and myeloid cells | |||
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Latest revision as of 08:49, 9 May 2023
- Summary
- A T cell marker that has value for demonstrating T-lineage in specific diagnostic circumstances
- Background
CD1a is structurally related to major histocompatibility complex proteins and is thought to mediate the presentation of lipid and glycolipid antigens. CD1a expression is absent on very early thymocytes, but is acquired together with CD4 and CD8 as T cells develop in the thymus, then is lost in mature T cells.
- Diagnostic Use
- A marker of early T-lineage
- CD1A us useful in the identification of some cases of T-all and for showing T lineage in MPAL
- Absence of CD1A staining may be helpful in recognition of ETP-ALL
- Aberrant expression of CD1A is recognised to occur at both B cells and myeloid cells