CD1a: Difference between revisions
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Background | Background | ||
CD1a is structurally related to major histocompatibility complex proteins and is thought to mediate the presentation of lipid and glycolipid antigens. CD1a expression is absent on very early thymocytes, but is acquired together with CD4 and CD8 as T cells develop in the thymus, then is lost in mature T cells. | CD1a is structurally related to major histocompatibility complex proteins and is thought to mediate the presentation of lipid and glycolipid antigens. CD1a expression is absent on very early thymocytes, but is acquired together with CD4 and CD8 as T cells develop in the thymus, then is lost in mature T cells. | ||
Diagnostic Use | Diagnostic Use | ||
*A marker of early T-lineage | *A marker of early T-lineage | ||
*CD1A us useful in the identification of some cases of T-all and for showing T lineage in MPAL | *CD1A us useful in the identification of some cases of T-all and for showing T lineage in MPAL | ||
Revision as of 23:20, 8 May 2023
- Summary
- A T cell marker that has value for demonstrating T-lineage in specific diagnostic circumstances
Background
CD1a is structurally related to major histocompatibility complex proteins and is thought to mediate the presentation of lipid and glycolipid antigens. CD1a expression is absent on very early thymocytes, but is acquired together with CD4 and CD8 as T cells develop in the thymus, then is lost in mature T cells.
Diagnostic Use
- A marker of early T-lineage
- CD1A us useful in the identification of some cases of T-all and for showing T lineage in MPAL
- Expression is notably absent in ETP-ALL