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Difference between revisions of "CD138"

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:CD138 is useful in the identification of normal or malignant plasma cells having a high level of specificity
 
:CD138 is useful in the identification of normal or malignant plasma cells having a high level of specificity
  
*It is a valuable marker but used alone does not discriminate normal from abnormal cells and care with interpretation
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*It is a valuable marker but used alone does not discriminate normal from abnormal cells and care should be taken with interpretation
  
 
*Expression is expected in myeloma, but expression level may be low compared with normal plasma cells
 
*Expression is expected in myeloma, but expression level may be low compared with normal plasma cells
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<span style="color:navy">'''What is its diagnostic role?'''</span>  
 
<span style="color:navy">'''What is its diagnostic role?'''</span>  
  
*CD138 (used in conjunction with CD38, CD45 and light scatter) can identify plasma cells for the diagnosis or monitoring of myeloma.  
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*CD138 (used in conjunction with CD38, CD45 and light scatter profiles) can identify plasma cells for the diagnosis or monitoring of myeloma.  
 
*There is little aberrant expression on other haematopoietic cell types, but it is recognised that expression by neoplastic plasma cells may be weak, variable or absent in a proportion of cases.  
 
*There is little aberrant expression on other haematopoietic cell types, but it is recognised that expression by neoplastic plasma cells may be weak, variable or absent in a proportion of cases.  
*Expression is seen on cells with plasmacytoid differentiation in lymphoplasmacytoid lymphoma or marginal zone lymphoma, but not on the neoplastic B cells that do have plasma cell features
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*Expression is seen on those cells that have plasmacytoid differentiation in lymphoplasmacytoid lymphoma or marginal zone lymphoma, but is not found on sub-populations that do not have plasma cell features
  
  
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<gallery widths="40px" heights="40px" >
 
<gallery widths="40px" heights="40px" >
File:Rare.png|frame|''CLL''*|link=Flow cytometry key
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File:Rare.png|frame|''CLL''|link=Flow cytometry key
File:Rare.png|''PLL**''|link=Flow cytometry key
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File:Rare.png|''PLL''|link=Flow cytometry key
 
File:Rare.png|''MCL''|link=Flow cytometry key
 
File:Rare.png|''MCL''|link=Flow cytometry key
File:Rare.png|''FL'' *|link=Flow cytometry key
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File:Rare.png|''FL''|link=Flow cytometry key
File:Rare.png|''HCL**''|link=Flow cytometry key
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File:Rare.png|''HCL''|link=Flow cytometry key
 
File:Rare.png|''HCLv''|link=Flow cytometry key
 
File:Rare.png|''HCLv''|link=Flow cytometry key
File:Poss.png|''MZL'' *|link=Flow cytometry key
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File:Poss.png|''MZL''|link=Flow cytometry key
 
File:Freq.png|''LPL''|link=Flow cytometry key
 
File:Freq.png|''LPL''|link=Flow cytometry key
 
File:Hi.png|''PCs''|link=Flow cytometry key
 
File:Hi.png|''PCs''|link=Flow cytometry key
 
</gallery>
 
</gallery>
  
Notes: In MCL and LPL, expression is restricted to cells that have plasma cell features so population will be mixed; the lymphocyte component will be negative
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''In MCL and LPL, expression is restricted to those cells that have plasma cell features''
  
  

Latest revision as of 15:16, 10 October 2019


CD138 is useful in the identification of normal or malignant plasma cells having a high level of specificity
  • It is a valuable marker but used alone does not discriminate normal from abnormal cells and care should be taken with interpretation
  • Expression is expected in myeloma, but expression level may be low compared with normal plasma cells
  • Expression is seen in LPL or MZL, but only those cells that have plasma cell differentiation



Normal function and expression

CD138 is a glycosylated membrane protein (syndecan-1) that mediates cell adhesion, but can also bind and modify the function of cytokines and chemokines. In the hematopoietic system expression of CD138 is acquired by B lymphocytes as they develop into plasma cells, and is therefore expressed on both neoplastic and normal plasma cells with high specificity.


What is its diagnostic role?

  • CD138 (used in conjunction with CD38, CD45 and light scatter profiles) can identify plasma cells for the diagnosis or monitoring of myeloma.
  • There is little aberrant expression on other haematopoietic cell types, but it is recognised that expression by neoplastic plasma cells may be weak, variable or absent in a proportion of cases.
  • Expression is seen on those cells that have plasmacytoid differentiation in lymphoplasmacytoid lymphoma or marginal zone lymphoma, but is not found on sub-populations that do not have plasma cell features


Other relevant information:

Outside of haematopoiesis it is found on squamous epithelium.



SUMMARY TABLES


1. Expression by acute leukaemias and by haematogones


2. Expression by B-lymphoproliferative disorders

In MCL and LPL, expression is restricted to those cells that have plasma cell features



KEY


The indicated expression frequency, indicates the approximate frequency of occurrence in each particular disease type.


Rare.png

rare (<5%)

Poss.png

possible (5-20%)

Mod.png

likely (20-40%)

Freq.png

frequent (40-80%)

Hi.png

expected (>80%)


Where expression level is unusual or characteristic of a disorder this is indicated by text: