Actions

Difference between revisions of "CD11b"

From www.haemtologyetc.co.uk

 
Line 2: Line 2:
  
  
:During the later maturation of acute myeloid leukaemia particularly those with granulocytic maturation although also expressed on monocytes (although less so than CD11c); expression of CD11b may be used to support the identification of MPAL  
+
:Expressed during the later maturation of acute myeloid leukaemias particularly those with granulocytic maturation although also expressed on monocytes (although less so than CD11c); expression of CD11b may be used to support the identification of mixed phenotype acute leukaemia (MPAL)
  
  
Line 10: Line 10:
 
'''Usage'''
 
'''Usage'''
  
This is a leukocyte integrin receptor expressed by myeloid cells; in contrast to the closely related integrin receptor CD11c, CD11b is predominantly a marker of neutrophil maturation – being acquired after the more primitive blast cell stage then showing stronger expression as precursor cells mature.
+
This is a leukocyte integrin receptor expressed by myeloid cells; in contrast to the closely related integrin receptor CD11c, CD11b is predominantly a marker of neutrophil maturation –acquired after the more primitive blast cell stage then showing stronger expression as precursor cells mature.
  
  
 
----
 
----

Latest revision as of 15:20, 10 October 2019


Expressed during the later maturation of acute myeloid leukaemias particularly those with granulocytic maturation although also expressed on monocytes (although less so than CD11c); expression of CD11b may be used to support the identification of mixed phenotype acute leukaemia (MPAL)



Usage

This is a leukocyte integrin receptor expressed by myeloid cells; in contrast to the closely related integrin receptor CD11c, CD11b is predominantly a marker of neutrophil maturation –acquired after the more primitive blast cell stage then showing stronger expression as precursor cells mature.