Marker patterns in typical acute myeloid leukaemia
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CD45 expression in AML
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Typically expression of CD45 is less intense than normal T or B cells, with many cases showing variable expression with a wide spread of CD45 intensity.
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Markers of pimitive cell type expected in AML
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Marker
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Expectation
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Comment
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CD34
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frequently expressed most often in less differentiated forms of AML; expression often less intense than in lymphoid leukaemias
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TdT
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Expect weak restricted κ or λ or absent expression
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CD7
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Characteristic of CLL, usually less strong than on T cells
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