| Marker patterns in typical acute myeloid leukaemia
|
| CD45 expression
|
| Typically expression of CD45 is less intense than normal T or B cells, with many cases showing variable expression with a wide spread of CD45 intensity.
|
| Major markers useful in CLL diagnosis
|
| Marker
|
Freq
|
Level
|
Comment
|
| CD19
|
|
-
|
Expression is expected, but less strong than normal B cells
|
| κ/λ
|
|
|
Expect weak restricted κ or λ or absent expression
|
| CD5
|
|
-
|
Characteristic of CLL, usually less strong than on T cells
|
| CD23
|
|
-
|
Characteristic of CLL, although can rarely be weak or absent
|
| CD79b
|
|
wk
|
Expression is expected, but characteristically weak
|
| CD200
|
|
-
|
Characteristically positive in CLL and negative in MCL
|
| FMC7
|
|
|
May be expressed by atypical cases, generally absent
|
| Other relevant markers
|
| CD10
|
|
-
|
Infrequent in CLL, consider FL if detected
|
| CD11C
|
|
wk
|
Expressed in some cases, but tends to be weak
|
| CD20
|
|
wk
|
Expression is expected, but characteristically weak
|
| CD25
|
|
wk
|
Expressed by many cases of CLL but characteristically weak
|
| CD38
|
|
wk
|
Expressed by some cases of CLL, typically weak
|
| CD43
|
|
-
|
Similar to CD200, may be helpful in some cases
|
| CD103
|
|
-
|
Not expressed by CLL, consider HCL if found
|
| CD138
|
|
-
|
Predominantly expressed at plasma cell differentiation
|