Acute leukaemia types: Difference between revisions
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!colspan="3" style = "font-size:90%; background:#DAE8F2"|'''Markers with strong lineage specificity in AML''' | !colspan="3" style = "font-size:90%; background:#DAE8F2"|'''Markers with strong lineage specificity in AML''' | ||
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!colspan="3" style = "font-size:90%; background:white"|While not expressed by all cases, MPO can be considered to be lineage-defining marker in AML (or establishing myeloid lineage in MPAL). | !colspan="3" style = "font-size:90%; background:white"|While not expressed by all cases, when detected by flow cytomwtry MPO can be considered to be lineage-defining marker in AML (or establishing myeloid lineage in MPAL). | ||
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|colspan="1" style = "font-size:80%; width: 4%; |'''Marker''' | |colspan="1" style = "font-size:80%; width: 4%; |'''Marker''' |
Revision as of 13:58, 17 July 2023
Marker patterns in typical acute myeloid leukaemia | |||
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CD45 expression in AML | |||
Expression of CD45 is "weak" i.e. significantly less intense than normal T cells, B cells or monocytes. The typically low side scatter means that myeloid blast cells tend to form a relatively uniform population separate from lymphocytes on CD45/SSc plots. However, there is some variability releted to indididual subtypes. | |||
Markers of pimitive cell type expected in AML | |||
These markers are generally regarded as indicating less differentiated cells, so may be expressed by any acute leukaemia type. When strongly expressed they have some value in indicating T or B lineage. | |||
Marker | Expectation | Comment | |
CD34 | Frequently expressed, most often in less differentiated forms of AML. Expression often less intense than in lymphoid leukaemias | ||
TDT | Expressed particularly in less differentiated forms of AML. Often on a sub-population of cells; expression usually less intense than in lymphoid leukaemias | ||
CD7 | Similar to TdT, CD7 expression is recognised on a proportion of AML, usually those with less differentiated phenotype. Most consistently expressed in T-ALL. | ||
Markers with strong lineage specificity in AML | |||
While not expressed by all cases, when detected by flow cytomwtry MPO can be considered to be lineage-defining marker in AML (or establishing myeloid lineage in MPAL). | |||
Marker | Expectation | Comment | |
CD34 | Frequently expressed, most often in less differentiated forms of AML. Expression often less intense than in lymphoid leukaemias |