Acute leukaemia types: Difference between revisions
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|colspan="4" style = "font-size:90%; color:black;" |Typically expression of CD45 is less intense than normal T or B cells, with many cases showing variable expression with a wide spread of CD45 intensity. | |colspan="4" style = "font-size:90%; color:black;" |Typically expression of CD45 is less intense than normal T or B cells, with many cases showing variable expression with a wide spread of CD45 intensity. | ||
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!colspan=" | !colspan="3" style = "font-size:90%; background:#DAE8F2"|Markers of pimitive cell type expected in AML | ||
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|colspan="1" style = "font-size:80%; width: 4%; |'''Marker''' | |colspan="1" style = "font-size:80%; width: 4%; |'''Marker''' | ||
|colspan="1" style = "font-size:80%; width: 8%; |'''Expectation''' | |colspan="1" style = "font-size:80%; width: 8%; |'''Expectation''' | ||
|colspan="1" style = "font-size:80%; width: 80%; |'''Comment''' | |colspan="1" style = "font-size:80%; width: 80%; |'''Comment''' | ||
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|colspan="1" style = "font-size:90%; color:black;" |'''CD19''' | |colspan="1" style = "font-size:90%; color:black;" |'''CD19''' | ||
|colspan="1" style = "background:#004466;"| | |colspan="1" style = "background:#004466;"| | ||
|colspan="1" style = "font-size:84%;"|Expression is expected, but less strong than normal B cells | |colspan="1" style = "font-size:84%;"|Expression is expected, but less strong than normal B cells | ||
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|colspan="1" style = "width: 4%; font-size:90%; color:black;" |'''κ/λ''' | |colspan="1" style = "width: 4%; font-size:90%; color:black;" |'''κ/λ''' | ||
|colspan="1" style = "width: 8%; background:#00b8e6;"| | |colspan="1" style = "width: 8%; background:#00b8e6;"| | ||
|colspan="1" style = "font-size:80%;"|Expect weak restricted κ or λ or absent expression | |colspan="1" style = "font-size:80%;"|Expect weak restricted κ or λ or absent expression | ||
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|colspan="1" style = "font-size:90%; color:black;" |'''CD5''' | |colspan="1" style = "font-size:90%; color:black;" |'''CD5''' | ||
|colspan="1" style = "background:#004466;"| | |colspan="1" style = "background:#004466;"| | ||
|colspan="1" style = "font-size:80%;"|Characteristic of CLL, usually less strong than on T cells | |colspan="1" style = "font-size:80%;"|Characteristic of CLL, usually less strong than on T cells | ||
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Revision as of 12:02, 17 July 2023
Marker patterns in typical acute myeloid leukaemia | |||
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CD45 expression | |||
Typically expression of CD45 is less intense than normal T or B cells, with many cases showing variable expression with a wide spread of CD45 intensity. | |||
Markers of pimitive cell type expected in AML | |||
Marker | Expectation | Comment | |
CD19 | Expression is expected, but less strong than normal B cells | ||
κ/λ | Expect weak restricted κ or λ or absent expression | ||
CD5 | Characteristic of CLL, usually less strong than on T cells | ||
CD23 | - | Characteristic of CLL, although can rarely be weak or absent | |
CD79b | wk | Expression is expected, but characteristically weak | |
CD200 | - | Characteristically positive in CLL and negative in MCL | |
FMC7 | May be expressed by atypical cases, generally absent | ||
Other relevant markers | |||
CD10 | - | Infrequent in CLL, consider FL if detected | |
CD11C | wk | Expressed in some cases, but tends to be weak | |
CD20 | wk | Expression is expected, but characteristically weak | |
CD25 | wk | Expressed by many cases of CLL but characteristically weak | |
CD38 | wk | Expressed by some cases of CLL, typically weak | |
CD43 | - | Similar to CD200, may be helpful in some cases | |
CD103 | - | Not expressed by CLL, consider HCL if found | |
CD138 | - | Predominantly expressed at plasma cell differentiation |