- Gene affected:
- ZRSR2 - Zinc Finger CCCH-Type, RNA Binding Motif And Serine/Arginine Rich 2
- Clinical significance
- Associated with MDS, AML and CMML cases, however the prognostic implications are unclear at present.
Function of gene
ZRSR2 forms part of the spliceosome complex. Spliceosome mutations are thought to promote malignancy through missplicing of genes involved in epigenetic regulation, transcription, and genome integrity.
NGS panel gene coverage
Associated genetic features: Often associated with TET2 which may affect the prognosis. Mutually exclusive with SFSF2 and U2AF1.
- GeneWiki link:
- 1. ZRSR2 in MDS