- Gene affected:
- STAG2 - Cohesin subunit SA-2
- Clinical significance
- The prognostic implications of STAG2 is an evolving field and currently there are no prognostic implications.
Function of gene
STAG2 forms part of the spliceosome complex. Spliceosome mutations are thought to promote malignancy through missplicing of genes involved in epigenetic regulation, transcription, and genome integrity
NGS panel gene coverage
Associated genetic features: Mutually exclusive with other cohesion complex molecules (STAG1, SMC1A, SMC3/RAD21). Associated with ASXL1/RUNX1/NPM1.
- GeneWiki link: