- Gene affected:
- SETBP1 - SET binding protein
- Clinical significance
- Associated with several myeloid conditions, especially atypical CML. Associated with a poorer overall survival.
Function of gene
SETBP1 binds with SET nuclear oncoprotein to form a heterodimer complex which is thought to inhibit the activity of protein phosphatase type 2A (PP2A), a tumour suppressor, and increases the rate of cell proliferation
NGS panel gene coverage
Associated genetic features: Associated with Monosomy 7 and ASXL1.
- GeneWiki link: