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Ring nuclei

From www.haematologyetc.co.uk


Appearance

The nucleus does not have separate lobes and instead has the appearance of a ring (or doughnut).



Images of ring nuclei

Most frequently a feature of MDS that is closely associated with reduced nuclear lobation, the cells usually show other dysplastic features such as cytoplasmic vacuolation and immaturity (image 1 – a nice double ring), increased chromatin density and reduced cell size (image 2) or a combination of features (image 3).



Cause

This appearance occurs in myeloproliferative disorders or myelodysplastic syndromes and rarely in normal or reactive states; most frequently a ring appearance accompanies other hypolobated cells (pseudo-Pelger forms).


Significance

Can contribute to a diagnosis of myelodysplasia or myeloproliferative disorder (together with other diagnostic features).