Neutrophils indexed according to shared functional or structural features
From www.haematologyetc.co.uk
General features
Normal neutrophils have a very characteristic form with easily recognised segmented nuclei and cytoplasmic granules.
This section describes:
- The normal nuclear segmentation of neutrophils
Artefactual features
This section describes changes that are generally regarded as being artefacts of sample storage, EDTA-anticoagulation or film preparation.
The section includes:
- Agglutination of neutrophils
- Apoptotic neutrophils
- Platelet satellitism
Reactive features
This section describes features that are most often associated with reactive states.
- Detached nuclear fragment
- Döhle bodies
- Macropolycytes
- Toxic granulation
- Vacuolation
Phagocytosis
Neutrophils are phagocytic cells, but the process generally occurs in tissues; however phagocytosed material in neutrophils is seen in a number of conditions.
This section includes:
- Phagocytosis of erythrocytes
- Phagocytosis of bacteria
- Phagocytosis of malaria pigment
Inherited disorders affecting neutrophils
A range of inherited conditions affect neutrophil morphology. These may affect nucleus, granulation, cytoplasm or produce added features.
This section includes:
- Alder-Reilly anomaly
- Chédiak-Higashi syndrome
- Döhle-like bodies
- Jordans' anomaly
- Pelger-Huët anomaly
Neoplastic involvement of neutrophils
Neoplasias (AML, MDS, MPD) can each produce characteristic morphological change to neutrophils, although some features are more specific than others.
This section includes:
- Agranular and hypogranular neutrophils
- Atypical nuclear shapes
- Auer rods in neutrophils
- Pseudo Chédiak-Higashi cells
- Pseudo Pelger-Huët anomaly
- Ring nuclei