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Marker profiles in B-LPD

From www.haematologyetc.co.uk


Interpretation of flow panel for different B-cell Lymphoproliferative disorders:

(click condition title for more)


A

ATLL


B


B-prolymphocytic leukaemia

B-PLL has no entirely specific marker pattern, and the immunophenotype overlaps with related conditions. However, features of the immunophenotype may suggest or support diagnosis of this condition


C


Chronic lymphocytic leukaemia

The immunophenotype of CLL may be entirely typical allowing confident diagnosis. However, a significant proportion of CLL cases will express atypical markers



F


Follicular lymphoma

FL has precise immunophenotype, but there are significant elements of the immunophenotype that suggest the diagnosis. Confirmation then requires correlation with clinical and pathological features



H

Hairy cell leukaemia and hairy cell variant

HCL has a characteristic immunophenotype phenotype that allows diagnosis with some certainty in typical disease. There is however an overlap with the variant form of HCL and to a lesser extent marginal zone lymphoma.



M


Marginal zone lymphomas

There is a significant variability in phenotype within the different MZL types and overlap with featureswith other disorders


Monoclonal B-lymphocytosis

A clonal lymphocyte population where the circulating number of clonal B cells and clinical features are is insufficient to diagnose a lymphoproliferative disorder


Myeloma and plasma cell leukaemia

Sometimes a difficult diagnosis by immunophenotype, often requires a combined diagnostic approach