Marker profiles in B-LPD


Interpretation of flow panel for different B-cell Lymphoproliferative disorders:

(click condition title for more)




B-prolymphocytic leukaemia

B-PLL has no entirely specific marker pattern, and the immunophenotype overlaps with related conditions. However, features of the immunophenotype may suggest or support diagnosis of this condition


Chronic lymphocytic leukaemia

The immunophenotype of CLL may be entirely typical allowing confident diagnosis. However, a significant proportion of CLL cases will express atypical markers


Follicular lymphoma

FL has precise immunophenotype, but there are significant elements of the immunophenotype that suggest the diagnosis. Confirmation then requires correlation with clinical and pathological features


Hairy cell leukaemia and hairy cell variant

HCL has a characteristic immunophenotype phenotype that allows diagnosis with some certainty in typical disease. There is however an overlap with the variant form of HCL and to a lesser extent marginal zone lymphoma.


Marginal zone lymphomas

There is a significant variability in phenotype within the different MZL types and overlap with featureswith other disorders

Monoclonal B-lymphocytosis

A clonal lymphocyte population where the circulating number of clonal B cells and clinical features are is insufficient to diagnose a lymphoproliferative disorder

Myeloma and plasma cell leukaemia

Sometimes a difficult diagnosis by immunophenotype, often requires a combined diagnostic approach