Immunophenotypic diagnosis of lymphoplasmacytoid cells
The following markers may be helpful in LPL diagnosis:
1. Antigens associated with plasma cell differentiation (often only expressed by a sub-population of cells): CD38 and CD138 co-expression is the most common pattern, but less frequently than for plasma cells
Note Where markers are atypical consider other diagnoses: click for summary
REPORTING OF IMMUNOPHENOTYPE
Reports will read: Cells in this sample have the immunophenotypic characteristics of lymphoplasmacytoid cells. This population comprises x% of cells. In this case the characteristic markers are: x, y, z. This should be correlated with clinical and biochemical testing. Molecular tests may be helpful in this disorder.