- Gene affected:
- HRAS gene - from RAS (rat sarcoma gene family). This form was identified originally associated with the Harvey Sarcoma virus - hence HRAS
- Clinical significance
- HRAS mutation may occur in myeloid or other haematological disorders but is infrequent. There is no clear prognostic significance attributed to the gene.
Function of gene
HRAS is a member of the RAS oncogene family originally isolated from the Harvey sarcoma virus and appears least commonly associated with myeloid disorder when compared with NRAS or KRAS. All RAS proteins are small GTP/GDP-linked signal proteins (i.e. they are activated when bound to GTP and inactive when GDP is bound) that act as on/off switches associated with various signal pathways.
NGS panel gene coverage
The panel recognises mutation affecting exons 2 or 3
Generally the most frequent RAS oncogenic mutation in haematology involve NRAS, with mutation of KRAS being less frequent and involvement by HRAS being rare.
Associated genetic features:' Mutations affecting members of the RAS family generally do not occur together with other mutations simultaneously affecting cell-signal related proteins (BCR/ABL1 or FLT3). Also lesions affecting multiple RAS family members are rarely seen.
- GeneWiki link: