Döhle bodies



Single or multiple inclusions appearing as irregular ovals with a pale blue colour, most frequently located peripherally in the neutrophil cytoplasm. They may be difficult to spot within the surrounding neutrophil hypergranularity.

Images of Döhle bodies

These are indistinct and roughly oval pale blue structures that displace the normal granules of the cell (images 1 & 1a). They may be difficult to detect in hypergranulation (images 2 and 2a). In both examples they are peripherally positioned.

Described by:

The German pathologist Karl Gottfried Paul Döhle in 1911.


Döhle bodies are believed to represent residual rough endoplasmic reticulum, and arise in conditions of accelerated neutrophil maturation or stress.

Distinguish from:

Do not confuse with Döhle-like bodies that are characteristic of LYST disorders (lysosomal tracking regulator). These are most recognisable in the May Hegglin anomaly and have a distinct appearance and significance (see separate description).